Lipodissolve, Injection lipolysis, Lipostabil, Mesofat…these terms all refer to the same treatment. It is the procedure which helps dissolve or melt fat.

It’s been around for at least 30 years and is widely used in Europe.

Basically, it involves a series of micro-injections of chemicals which dissolves localized areas of fat deposits. Cold spray might be applied in order to reduce the discomfort caused by the 30G needle.

The results are variable and dependent on the size of the area treated. The majority of individuals show a loss of at least 1-5 cm per treatment.

The highest fat loss typically occurs in the waist or belly and the lowest fat loss occurs in the legs. Patients may require 1- 5 sessions, and at least 2 weeks are allowed in between each session to allow the full effect of the therapy.

The results are gradual and it might take 1-3 weeks to become noticeable in smaller areas.

The side-effects are redness, bruising, moderate to severe edema, localized heat, slight to moderate itching. It normally occurs 2-5 days after injection and gradually disappears after 3-7 days. Edema can be reduced by compression of treated area by modeling belt or compressive clothing.

It is important to note that results are not permanent. If the individual gains weight, the fat will return. The best results are obtained when physical activity and dietary changes are continued after injection.

And do remember also, that this is not a weight loss program, the purpose is to remove localized fat deposits and shape your body.

This treatment is not for pregnant women, nursing mothers, obese patients; or people with diabetes, autoimmune diseases, vascular complications, or infections of any kind. It is important to note that it is not an appropriate treatment for large areas of fat.


The main ingredients in solutions injected into the fat cell are Phosphatidylcholine (PPC) and L-Carnitine.

PPC is a soy lecithin substance which is the exact chemical compound in our cell membranes. Clinical results reflect that PPC is efficacious in reducing the fatty pads in the treated areas.

It can alter cholesterol and other triglyceride metabolisms. It seems to be able to increase cholesterol solubility, alter the composition of fat deposits, and inhibit plaque aggregation. The action mechanisms of phosphatidylcholine injections in the subcutaneous tissue have not yet been explained.

It is supposed that the medication penetrates fat cell, acting as an emulsifying agent. The characteristics of the stored lipids would therefore be altered, making them water soluble. This would permit their elimination due to their non-compatibility with the material stored in the adipocyte which is liposoluble. However, there is no study that ratifies such a supposition.

L-Carnitine is made in the body from the amino acids lysine and methionine. It increases the use of fat as an energy source by transporting fatty acids into the mitochondria, where they are ‘burned’ to release energy for body functions.

Its enhancement of metabolism has been proven to prevent ischemia-induced heart dysfunction, and it has been suggested to delay the progression of Alzheimer’s disease. L-carnitine is found naturally in avocados, breast milk, dairy products, red meats (namely lamb and beef), and tempeh (fermented soybean product).

A deficiency of L-Carnitine can cause muscle fatigue, cramps, or low blood-sugar levels. L-Carnitine has been used to increase body metabolic rate and for athletes, the protein will help to convert fats into muscles mass during activities. It also shows to have anti-aging properties and regular supplement increases the body immune system by eliminating toxins from the body, for the production of Porphyrin which is needed to produce red blood cells.

In addition to an injection of lipodissolve solution, I have recently found another method of injection: injecting L-Carnitine alone into subcutaneous layer to melt localized fat or injecting it intravenously to increase metabolic rate and get systemic effects. This injection should be done every 2-3 days. Patient might experience some light gastrointestinal disturbance and therefore some food may be taken prior to the injection.

With any of these treatments, each individual should have an examination and discussion with the physician as the results are various. It might not be suitable for every one.

Dr Thanaruch Thanakorn

For more information, please contact dr.thanarch@phuketlaser.com or call 076 341 689